Intimate Expression: An Orphan’s Experience of Healing

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GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

Snippert, H. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science , — Barker, N. Lgr proteins in epithelial stem cell biology. Development , — Sharir, H. Hattori, N. MMP plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. Schmidt, B. Intradermal adipocytes mediate fibroblast recruitment during skin wound healing.

Kim, K-T. High-power femtosecond-terahertz pulse induces a wound response in mouse skin. Blanpain, C. Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science , Ito, M. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Levy, V. Epidermal stem cells arise from the hair follicle after wounding.

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Langton, A. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. Lu, C. Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Common structural basis for constitutive activity of the ghrelin receptor family.

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GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology , 13—20 Lauwers, E. Obestatin does not activate orphan G protein-coupled receptor GPR Bassilana, F. Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR Le, H. Hedgehog signaling is essential for normal wound healing. Wound Repair Regen. Luo, J.

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Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes. Allen, M. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.

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Intimate Expressions: An Orphan's Experience of Healing is a book about the path to survival and love. The book chronicles Dennis's bleak childhood as a ward. Intimate expression an orphan's experience of healing /​ Dennis J. Dodt. Author. Dodt, Dennis J, (author.) Published. [Bloomington, Indiana] Trafford Publishing.

U S A Suppl 1 , — Moechars, D. Altered gastrointestinal and metabolic function in the GPRobestatin receptor-knockout mouse. Gastroenterology , — Kuang, H. Cell Physiol. Download references.

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We thank members of the Duan laboratory for comments and suggestions. We thank Ms. Tong Zhao at the Institute of Microbiology, Chinese Academy of Sciences for her kind help with flow cytometric experiments. Zhao, S. Zhao, J.

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Zhang, X. Correspondence to Shuang Liu or Enkui Duan. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To obtain permission to re-use content from this article visit RightsLink. By submitting a comment you agree to abide by our Terms and Community Guidelines.

If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Article metrics. Advanced search. Skip to main content. Subjects Gene expression Skin stem cells.

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Introduction G protein-coupled receptors GPCRs mediate multiple key biological processes in the body. Results Unique promoter activity and mRNA expression of Gpr39 in SGs Using a previously described mouse model in which targeted insertion of the lacZ reporter gene disrupted the Gpr39 locus, we monitored the expression of Gpr39 by staining with X-gal. Full size image. Figure 3: Expression dynamics of GPR39 after wounding.

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Discussion Although the Gpr39 gene was cloned in 13 , research on its biological function has only emerged over the last 10 years. References 1.

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PubMed Article Google Scholar 9. PubMed Article Google Scholar PubMed Google Scholar CAS Google Scholar Google Scholar There were childhood wounds beneath our most irritating behaviors. A pattern of relating to others was set in motion long before each of us met our spouse.

Our childhood experiences and the way our parents related to us have imprinted certain thought patterns and behaviors on us. Milan and I call these imprints "love styles.