Inhalation Drug Delivery: Techniques and Products (Postgraduate Pharmacy Series)

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Topics include process engineering in the drug discovery, high throughput characterization and optimization of new chemical entities, solid-state engineering, and intelligent pharmaceutical manufacturing systems. Lectures, problems, and Internet and library study will be used to develop the ideas presented. Prerequisites: Senior or graduate standing, permission of instructor. Instructor: Amidon Terms: Winter.

Pharmaceutical Sciences Investigations in Pharmaceutics Credits: Original investigation of a laboratory or library problem to be selected after consultation with the instructor. A paper is required. Prerequisites: PharmD students. Permission of instructor. Pharmaceutical Sciences Pharmacokinetic Concepts and Applications Credits: 4 This course is the third of four required courses in the pharmaceutical sciences curriculum. Course content includes the absorption, distribution, metabolism, and excretion of drugs and drug-related species by the body.

Additional emphasis is placed on designing suitable dosage regimens for the treatment and prevention of disease in humans. Three lecture hours and one discussion hour a week. This entry level course is designed for 1st or 2nd year graduate students in the pharmaceutical or related biomedical sciences. Instructor: Smith Terms: Fall. This course focuses on the physical chemistry of drugs and drug delivery systems.

Thermodynamic principles, solution and interfacial phenomena, solubility, and solid state properties will be emphasized with a focus primarily on small molecules. These physicochemical principles will be applied to the design, characterization, and performance of a variety of drug delivery systems. This course focuses on the biological and molecular concepts of drug design, delivery and targeting. The fundamental principles of cell biology and molecular biology will be applied to drug design, targeted drug delivery, and cellular drug delivery.

Nano-Pharmacology and Drug Targeting

This course focuses on the fundamentals of rate processes pertaining to drug delivery. Rate processes will include both physical i. An introduction to these concepts will be provided including both qualitative and quantitative treatment. Mass transfer will be applied to drugs moving in solution, dissolving from solid dosage forms, and traversing polymer and biological membranes. Decomposition of drugs will be examined in solution, in the solid state, and within dosage forms. Prerequisites: Math Differential Equations completed or taken concurrently.

Graduate student standing or permission of instructor. Instructor: Schwendeman Terms: Fall. Pharmaceutical Sciences Analytical Methods in Drug Delivery Credits: 2 The aim of this course is to present students with a broad range of topics and also in-depth treatment on selected analytical methods and techniques that have been used in the design and characterization of various pharmaceutical products: from small molecules to biologics. Pharmaceutical Sciences Nanotechnology for Drug Delivery Credits: 2 This course will detail recent advances made in the interdisciplinary field of nanomedicine for students with physical, chemical, or biological sciences background.

This course will focus on emerging nanotechnologies, and their biomedical applications, including nanomaterials, nanoparticle-based drug delivery systems, nano-based thranostics, and translation of nanomedicine into clinical trials and commercialization. Pharmaceutical Sciences Biologic Products: Recombinant Proteins, Cell Therapies and Biosimilars Credits: 2 In the top selling drugs are monoclonal antibodies, and half of the new drugs approved are biopharmaceuticals and numerous biosimilars are being developed.

This class is about how biologic drugs are discovered, manufactured, formulated, analyzed, developed and regulated - now essential information for scientists seeking careers in the pharmaceutical industry. Pharmaceutical Sciences Pharmaceutical Solids Credits: 2 Formation and properties of pharmaceutical solids. Prerequisites: Graduate student standing or senior undergraduate student standing. Completion of PharmSci , Chem , or equivalent. This component of the series includes the written research proposal.

A grade will be submitted upon the successful submison and final approval of the proposal by the PharmD Investigations Committee.

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Pharmaceutical Sciences Micropharmacokinetics: Cellular Drug Transport Credits: 2 This course will teach students how to immerse themselves in the environment of cells: picoliter volumes with nanograms of materials containing a few femtomols of drug with hundreds of transporters pumping thousands of molecules per second. Pharmaceutical Sciences Biopharmaceutical Engineering [Cross-listed with CHE and MFG ] Credits: 3 This course covers fundamental concepts essential for the discovery, development, manufacturing, formulation and characterization of biopharmaceuticals.

Topics inlcude basic immunology, antibody discovery and engineering, emerging therapeutic modalities, vaccines, product quality and analytics, biosimilars, cell culture, purification and formulation.

Pharmaceutical Sciences (PhD)

The course will cover the oral absorption and metabolism of drugs from a classical and modern molecular perspective including discussion of current FDA Bioequivalence BE regulatory standards. It will also cover the most recent advances in pharmacogenomic and genetic test methods particularly as they relate to the selectivity and variability, in patients, of drug toxicity and efficacy.

This semester of the series is designed for students to obtain hands on experience in conducting their research and collecting and analyzing all research data. Students work under the supervision of their faculty mentor to develop data collection forms and methods to archive data in a way that facilitates their analysis.

Pharmaceutical Sciences Entrepreneurship in Pharmacy Credits: 1. Pharmaceutical care has an important role to play in improving patient care in these areas. Ms Boyter is lecturer in clinical practice, department of pharmaceutical sciences, University of Strathclyde and principal pharmacist, Glasgow Royal infirmary and Greater Glasgow practice unit; Mrs Currie is Lloyds teacher-practitioner, pharmaceutical care health service unit, University of Strathclyde; Dr Dagg is specialist registrar in respiratory medicine, Glasgow Royal infirmary; Mrs Groundland is Boots teacher-practitioner, pharmaceutical care health service unit, University of Strathclyde; and Professor Hudson is Boots professor of pharmaceutical care, pharmaceutical care health service unit and Scottish Office national specialist in pharmaceutical care Other articles in the series Pharmaceutical care 6 Gastro-oesophageal reflux disease Pharmaceutical care 7 Arthritis References 1.

American Thoracic Society.

Drug Formulation Congress 12222

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease COPD and asthma. Am Rev Respir Dis ; British guidelines on asthma management. Thorax ;S The changing epidemiology of asthma. Scot Med J ; Measurement of outcomes in adults receiving pharmaceutical care in a comprehensive outpatient clinic.

Pharmacotherapy ; British Thoracic Association. Death from asthma in two regions of England. BMJ ; Thorax ; Respiratory Medicine. London: WB Saunders, Sturevany J. N Z Dent J ; Szezeklik A, Stevenson DD. Aspirin induced asthma: advances in pathogenesis and management. J Allergy Clin Immunol ; Tavakkoli A, Rees PJ. Drug treatment of asthma in the s: achievements and new strategies.

Drugs ; Guidelines for the management of asthma in adults. Chronic persistent asthma. Acute severe asthma. Guidelines for the management of asthma. Lipworth BJ. Leukotriene-receptor antagonists.

Inhalational Drug Administration

Lancet ; Rees J, Price J. ABC of asthma; treatment of chronic asthma. A UK consensus group on the management of glucocorticoid-induced osteoporosis: an update. J Intern Med ; Brittle asthma. Hindle M, Chrystyn H.

Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices. Evaluation of the effect of a large volume spacer on the systemic bioactivity of fluticasone propionate metered dose inhaler.

  1. Inhalation Drug Delivery: Techniques and Products.
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Chest ; Crompton GK. Do large volume spacer devices reduce the systemic effects of high dose inhaled corticosteroids? Delivery of propellant soluble drug from a metered dose inhaler. Inability of physicians to use metered-dose inhalers.

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J Asthma ; Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. Eur Respir J ; Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery. Current best practice for nebuliser treatment. Drug delivery in asthma: a comparison of spacers with a jet nebuliser.

Aust N Z J Med ; Is high-dose fluticasone propionate via a metered dose inhaler and Volumatic as efficacious as nebulized budesonide in adult asthmatics? Respir Med ; Effectiveness of self monitoring of peak flow in patients with asthma. Peak flow based asthma self management: a randomised controlled study in general practice.

British Thoracic Society Research Committee. Thorax Lahdensuo A. Guided self management of asthma - how to do it. Focus on corticosteroids. Current Problems in Pharmacovigilance ; A comparison of low dose inhaled budesonide plus theophylline and high dose inhaled budesonide for moderate asthma. N Engl J Med ; Immunomodulation of theophylline in asthma, demonstration by withdrawal therapy.

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There has been a rapid evolution in the field of inhalation drug therapy, Focusing on inhalation products and specific equipment and techniques used in . There has been a rapid evolution in the field of inhalation drug therapy, Focusing on inhalation products and specific equipment and techniques used Pharmaceutical Development Studies for Inhalation Postgraduate Pharmacy Series.

Acute angle glaucoma as a complication of combined beta-agonist and ipratropium therapy in the emergency department. Ann Emerg Med ; Nebulised ipratropium and salbutamol causing closed angle glaucoma. Leukotriene receptor antagonists: an update on adverse reaction profiles. The role of the pharmacist in improving asthma care. National education and prevention programme. Am Pharm ; Effects of an asthma management program on the asthmatic member: patient centred results of a two-year study in a managed care organisation.